Journal of Medical and Surgical
Research (JMSR)


Pages: 377-379

Date of Publication: 30-Nov--0001

Caudal Regression Syndrome: a Compelling Picture to Call for Maternal Diabetes Prevention,
Screening and Management During Pregnancy

Author: Imane Khachani, Salma Ouassour, Kanza Chafchaouni, Amina Barakat, Zakia Tazi Mokha, Abdelhai Filali Adib, Chafik Chraibi, Mohamed Hassan Alami, Rachid Bezad.

Category: JMSR Diabetes & Endocriniology

[Download PDF]


We report the case of a newborn with caudal regression syndrome, due to maternal diabetes with inadequate management, treatment and surveillance during pregnancy.

Keywords: Caudal Regression, Diabetes, Prenatal Care, Prevention.


  1. Duhamel, B. Malformations ano-rectales et anomalies vertébrales. Arch. franç. Pediat. 1959;16, 534.
  2. Passarge, E., and Lenz, W. Syndrome of caudal regression in infants of diabetic mothers : observations of further cases. Pediatrics 1966; 37, 672-675.
  3. Pang D. Sacral agenesis and caudal spinal cord malformations. Neurosurgery. 1993; 32(5): 755-79.
  4. Ornoy A. Embryonic oxidative stress as a mechanism of teratogenesis with special emphasis on diabetic embryopathy. Reprod Toxicol. 2007 Jul;24(1):31-41.
  5. Stewart J., Stoll S. Familial caudal regression anomalies and maternal diabetes Journal of Medical Genetics, 1979;16, 17-20.
  6. Correa A, Gilboa SM, Besser LM, et al. Diabetes mellitus and birth defects. Am J Obstet Gynecol 2008;199:237.e1-237.e9.