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<Journal>
<PublisherName>journal-jmsr</PublisherName>
<JournalTitle>Journal of Medical and Surgical Research</JournalTitle>
<PISSN>I</PISSN>
<EISSN>S</EISSN>
<Volume-Issue>Vol. XII, n 1</Volume-Issue>
<PartNumber/>
<IssueTopic>Multidisciplinary</IssueTopic>
<IssueLanguage>English</IssueLanguage>
<Season>June 2025</Season>
<SpecialIssue>N</SpecialIssue>
<SupplementaryIssue>N</SupplementaryIssue>
<IssueOA>Y</IssueOA>
<PubDate>
<Year>2025</Year>
<Month>08</Month>
<Day>31</Day>
</PubDate>
<ArticleType>JMSR Pediatrics</ArticleType>
<ArticleTitle>Epidemiological and Clinical Profile of Newborns with Trisomy 21 in Rabat- Morocco: A Five-Year Period Study</ArticleTitle>
<SubTitle/>
<ArticleLanguage>English</ArticleLanguage>
<ArticleOA>Y</ArticleOA>
<FirstPage>1459</FirstPage>
<LastPage>1464</LastPage>
<AuthorList>
<Author>
<FirstName>Karima</FirstName>
<LastName>Rahali</LastName>
<AuthorLanguage>English</AuthorLanguage>
<Affiliation/>
<CorrespondingAuthor>N</CorrespondingAuthor>
<ORCID/>
<FirstName>Afaf</FirstName>
<LastName>Chenaichek</LastName>
<AuthorLanguage>English</AuthorLanguage>
<Affiliation/>
<CorrespondingAuthor>Y</CorrespondingAuthor>
<ORCID/>
<FirstName>Amina</FirstName>
<LastName>Barkat</LastName>
<AuthorLanguage>English</AuthorLanguage>
<Affiliation/>
<CorrespondingAuthor>Y</CorrespondingAuthor>
<ORCID/>
</Author>
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<DOI>10.46327/msrjg.1.000000000000272</DOI>
<Abstract>Introduction: Trisomy 21 is the most common chromosomal abnormality with a prevalence of 1/700 to 1/1000 live births. In Morocco, epidemiological data remains limited. This study aimed to describe the epidemiological and clinical profile of patients with trisomy 21 in the Rabat region over five years. Materials and Methods: This was a retrospective descriptive and analytic study of two complementary cohorts: one cohort of patients followed in outpatient consultation and one cohort of newborns diagnosed in the delivery room. Demographic, clinical data and comorbidities were analyzed using SPSS version 26.0. Results: The total population studied included 136 patients with 50.7% male newborns. Congenital hypothyroidism was the most frequent associated comorbidity (55.9%), followed by congenital heart disease (6.5%). Consultations paradoxically increased during the COVID-19 pandemic (33 in 2020, 105 in 2022). The mean maternal age in the neonatal cohort varied from 39.5 years in 2021 (100% ?35 years) to 32.8 years in 2023. Conclusion: The high prevalence of congenital hypothyroidism and the low rate of documented heart disease suggest the need to adapt screening protocols to the Moroccan context. The impact of the COVID-19 pandemic revealed vulnerabilities in access to care, particularly for young mothers. Systematic screening for comorbidities and a multidisciplinary approach are essential to optimize care.</Abstract>
<AbstractLanguage>English</AbstractLanguage>
<Keywords>Trisomy 21, Down syndrome, epidemiology, Morocco, comorbidity</Keywords>
<URLs>
<Abstract>https://www.journal-jmsr.net/ubijournal-v1copy/journals/abstract.php?article_id=15956&title=Epidemiological and Clinical Profile of Newborns with Trisomy 21 in Rabat- Morocco: A Five-Year Period Study</Abstract>
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<References>
<ReferencesarticleTitle>References</ReferencesarticleTitle>
<ReferencesfirstPage>16</ReferencesfirstPage>
<ReferenceslastPage>19</ReferenceslastPage>
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