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<PublisherName>journal-jmsr</PublisherName>
<JournalTitle>Journal of Medical and Surgical Research</JournalTitle>
<PISSN>I</PISSN>
<EISSN>S</EISSN>
<Volume-Issue>Special Issue "Pathology"</Volume-Issue>
<PartNumber/>
<IssueTopic>Multidisciplinary</IssueTopic>
<IssueLanguage>English</IssueLanguage>
<Season>March, 2023</Season>
<SpecialIssue>N</SpecialIssue>
<SupplementaryIssue>N</SupplementaryIssue>
<IssueOA>Y</IssueOA>
<PubDate>
<Year>-0001</Year>
<Month>11</Month>
<Day>30</Day>
</PubDate>
<ArticleType>JMSR Pathology</ArticleType>
<ArticleTitle>Granulomatous mycosis fungoides: report of three cases and review of the literature.</ArticleTitle>
<SubTitle/>
<ArticleLanguage>English</ArticleLanguage>
<ArticleOA>Y</ArticleOA>
<FirstPage>1147</FirstPage>
<LastPage>1147</LastPage>
<AuthorList>
<Author>
<FirstName>L.</FirstName>
<LastName>Benbella</LastName>
<AuthorLanguage>English</AuthorLanguage>
<Affiliation/>
<CorrespondingAuthor>N</CorrespondingAuthor>
<ORCID/>
<FirstName>I.</FirstName>
<LastName>Elouarith</LastName>
<AuthorLanguage>English</AuthorLanguage>
<Affiliation/>
<CorrespondingAuthor>Y</CorrespondingAuthor>
<ORCID/>
<FirstName>S.</FirstName>
<LastName>Sassi</LastName>
<AuthorLanguage>English</AuthorLanguage>
<Affiliation/>
<CorrespondingAuthor>Y</CorrespondingAuthor>
<ORCID/>
<FirstName>O.</FirstName>
<LastName>Essadeq</LastName>
<AuthorLanguage>English</AuthorLanguage>
<Affiliation/>
<CorrespondingAuthor>Y</CorrespondingAuthor>
<ORCID/>
<FirstName>Z.</FirstName>
<LastName>Loubaris</LastName>
<AuthorLanguage>English</AuthorLanguage>
<Affiliation/>
<CorrespondingAuthor>Y</CorrespondingAuthor>
<ORCID/>
<FirstName>F.</FirstName>
<LastName>Zouaidia</LastName>
<AuthorLanguage>English</AuthorLanguage>
<Affiliation/>
<CorrespondingAuthor>Y</CorrespondingAuthor>
<ORCID/>
<FirstName> A. Jahid</FirstName>
<AuthorLanguage>English</AuthorLanguage>
<Affiliation/>
<CorrespondingAuthor>Y</CorrespondingAuthor>
<ORCID/>
<FirstName> Z.</FirstName>
<LastName>Bernoussi</LastName>
<AuthorLanguage>English</AuthorLanguage>
<Affiliation/>
<CorrespondingAuthor>Y</CorrespondingAuthor>
<ORCID/>
<FirstName>K.</FirstName>
<LastName>Znati</LastName>
<AuthorLanguage>English</AuthorLanguage>
<Affiliation/>
<CorrespondingAuthor>Y</CorrespondingAuthor>
<ORCID/>
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<DOI/>
<Abstract>Introduction: Granulomatous mycosis fungoides (GMF) is a rare form of cutaneous T-cell lymphoma that is a major diagnostic challenge.
The objective of this work is to relate the clinical and pathological aspects of this condition and to discuss its differential diagnoses.
Case reports: The cases included 3 patients with GMF, admitted to the dermatology department of Ibn Sina Hospital in Rabat. The first one is a 35 year-old female patient, diabetic, admitted for the management of a slowly growing erythematosquamous plaque formed on the abdomen, which rapidly ulcerated.
The second one is a 46 year-old female, with no medical history, presented with erythematous plaque of the neck, evolving for 3 weeks. The 3rd case corresponds to a 63-year-old male patient, treated since 2013 for Mycosis fungoides.
R__ampersandsigneacute;sultats: The histological study showed the same findings in the 3 patients, including the exocytosis of atypical lymphocytes in the epidermis and the presence of authentic epithelioid granulomas in the underlying dermis. The immunohistochemical study showed a negative staining of the anti-CD5 antibody (1st case), the anti-CD7 antibody (2nd case) and the anti-CD2 antibody (3rd case). The anti-CD30 antibody was negative in all 3 cases.
Discussion: Granulomatous MF, originally described in 1970, is a rare histological form, constituting 6.3% of MF described in the literature.
The clinical findings are nonspecific and the diagnosis is purely anatomo-pathological.
Histologically, the signs of classical MF are present, namely atypical lymphocytes in the dermis with epidermotropism. The granulomas are sarcoid-like, mixed with langhans giant cells.
Conclusion: To conclude, MFG is a rare histological form of cutaneous T-cell lymphoma that can histologically mimic infectious or inflammatory dermatosis and cause a delay in diagnosis. Anatomo-clinical correlation, good morphological analysis and immunohistochemical study help guide the diagnosis.</Abstract>
<AbstractLanguage>English</AbstractLanguage>
<Keywords>Mycosis fungoides, T-cell lymphoma, granulomas.</Keywords>
<URLs>
<Abstract>https://www.journal-jmsr.net/ubijournal-v1copy/journals/abstract.php?article_id=14383&title=Granulomatous mycosis fungoides: report of three cases and review of the literature.</Abstract>
</URLs>
<References>
<ReferencesarticleTitle>References</ReferencesarticleTitle>
<ReferencesfirstPage>16</ReferencesfirstPage>
<ReferenceslastPage>19</ReferenceslastPage>
<References>Gutte R, Kharkar V, Mahajan S, Chikhalkar S, Khopkar U. Granulomatous mycosis fun-goides with hypohidrosis mimicking lepromatous leprosy. Indian J Dermatol Venereol Lep-rol. 2010;76:686-90
Kempf W, Ostheeren-Michaelis S, Paulli M, Lucioni M, Wechsler J, Audring H, AL. Granulomatous mycosis fungoides and granulomatous slack skin. Ar Arch Derma-tol. 2008;144:1609-17.
Li JY, Pulitzer MP, Myskowski PL, et al. A case-control study of clinocopathologic features, prognosis, and therapeutic responses in patients with granulomatous mycosis fungoides. J Am Acad Dermatol. 2013;69:366-374.
Gallardo F, Garcia-Muret MP, Servitje O, et al. Cutaneous lymphomas showing prominent granulomatous component: clinicopathological features in series of 16 cases. JEADV. 2009; 23:639-647.</References>
</References>
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