Join us   Log in  



Pages: 599-610

Human Papillomavirus and Oral Cancer: Systematic Review 

Bouzoubaa Sidi Mohammed, O. Medaghri Alaoui, HS Najeh, I. Benyahya

Category: JMSR Oncology

Download PDF


Aim: The cause-and-effect relationship between human papillomavirus (HPV) in oral cavity carcinomas and potentially malignant lesions continues to be controversial. Objectives: The main objective of this work is to demonstrate this cause-effect relationship between HPV and oral cavity cancers as well as to identify the types of HPV involved in malignant oral diseases.

Materiels and methods: Our research was conducted using PubMed via Medline, Science Direct and SciVerse Scopus and we have selected studies that date back 10 years. Eligible studies included case-control clinical studies and cross-sectional studies. Our work is based on 20 clinical studies, 3 of which are cross-sectional and 17 are case-control studies.

Results: Of the 20 studies selected, 14 of 20 studies confirm that HPV is an important causative factor for the development of oral carcinomas, especially high-risk HPVs, HPV16 and HPV18, while 6 studies suggest that there is no relationship between the presence of HPV and oral malignant lesions.

Conclusion: The results suggest a significant causal association between HPV and oral carcinomas, but this does not preclude the need for prospective studies on young non-alcoholic-tobacco patients.

Keywords: Human Papillomavirus, Etiology, Lesion, Tumor., oral cancer


  1. Hamdoun R., Chbicheb S., El Wady W. Cancer de la cavité buccale : épidémiologie et Facteurs de risque Oral cancer: epidemiology and risk factors Web journal du dentist vol 6 N°1 Juin 2015
  2. Warnakulasuriya S. Global epidemiology of oral and oropharyngeal cancer. Oral Oncol.2009; 45 (4-5): 309–316.
  3. Registre de cancers de la région du grand Casablanca & Association Lalla Salma. Registre de cancers de la région du grand Casablanca 2005-2006-2007. Edition 2012.
  4. Ferlay J., Shin HR., Bray F., Forman D., Mathers C., Parkin DM. Cancer Incidence and Mortality Worldwide. IJC, Lyon, France 2010 ; 12:2893-2917
  5. Righini Christian Adrien, Karkas Alexandre, Morel Nils, Soriano Edouard, Reyt Emile Facteurs de risque des cancers de la cavité buccale, du pharynx (cavum exclu) et du larynx Presse Med. 2008 Sep;37(9):1229-40
  6. Vicente José Villagómez-Ortíza, Diana Estela Paz-Delgadilloa, Ivan Marino-Martínezb, Luis Angel Cesenas-Falconc, Anabel Sandoval-de la Fuentea, Alfonso Reyes-Escobedoa Prevalence of human papillomavirus infection in squamous cell carcinoma of the oral cavity, oropharynx and larynx Cirugía y Cirujanos. 2016;84(5):363---368
  7. Eversole Lewis.R, Laipis PJ. Oral Squamous Papillomas : detection of HPV DNA by in situ hybridization.Oral Surg Oral Med Oral Pathol 1988;65:545-50
  8. Young SK, Min KW. In situ DNA hybridization analysis of oral papillomas, leukoplakias, and carcinomas for human papillomavirus. Oral Surg Oral Med Oral Pathol 1991;71; 726-9
  9. Zeuss MS, Miller CS, White DK. In situ hybridization analysis of human papillomavirus DNA in Oral Mucosal lesions.Oral Surg Oral Med Oral Pathol 1991;71:714-20
  10. Lacau St Guily Jean, Clavel Christine, Agius Gérard Papillomavirus et tumeurs des voies aérodigestives supérieures (hors papillomatose juvénile) Mt pédiatrie, vol. 13, n° 1, janvier-février 2016
  11. Laco J, Nekvindova J, Novakova V, Celakovsky P, Dolezalova H, Tucek L, Vosmikova H, Vosmik M, Neskudlova T, Cermakova E, Hacova M, Sobande FA, Ryska A.Biologic importance and prognostic significance of selected clinicopathological parameters in patients with oral and oropharyngeal squamous cell carcinoma, with emphasis on smoking, protein p16INK4a expression, and HPV status Neoplasma. 2012;59(4):398-408
  12. Lucas-Roxburgh Rebecca, Benschop Jackie, Dunowska Magdalena, Perrott Matthew Prevalence of human papillomaviruses in the mouths of New Zealand womenN Z Med J. 2015 Sep 25;128(1422):45-52
  13. Gordon A. Pringle The Role of Human Papillomavirus in Oral Disease Dent Clin N Am 58 (2014) 385–399
  14. Suyamindra S Kulkarni, Sujayendra S Kulkarni, Priyanka P Vastrad, Bhushan B Kulkarni, Amruta R Markande, G.S.Kadakol, S.V.Hiremath, S.Kaliwal, B.R.Patil,Pramod B Gai Prevalence and Distribution of High Risk Human Papillomavirus (HPV) Types 16 and 18 in Carcinoma of Cervix, Saliva of Patients with Oral Squamous Cell Carcinoma and in the General Population in Karnataka, India. Asian Pac J Cancer Prev. 2011;12(3):645-8
  15. Laprise Claudie, Madathil Sreenath A., Allison Paul, Priya Abraham, Anantharam Raghavendran, Shahul Hameed P., ThekkePurakkal Akhil-Soman,Genevieve Castonguay, Coutlée François, Schlecht Nicolas F., Rousseau Marie-Claude, Nicolau Eduardo L. Franco and Belinda No role for human papillomavirus infection in oral cancers in a region in southern India Int J Cancer. 2016 Feb 15;138(4):912-7
  16. Kalavathy Jayapal Elango, Amritha Suresh, Elango Murugaian Erode,Lakshmi Subhadradevi, Hiran Kattilaparambil Ravindran, Subramania Kulathu Iyer, Sundaram Karimassery Rama Iyer, Moni Abraham Kuriakose Role of Human Papilloma Virus in Oral Tongue Squamous Cell Carcinoma Asian Pac J Cancer Prev. 2011;12(4):889-96.
  17. Mirghani Haitham Cancers de l’oropharynx et papillomavirus oncogènes. Gustave Roussy Cancer Campus grand paris 2014
  18. Munoz N, Bosch FX, de Sanjose S, Herrero R, Castellsague X,Shah KV, et al. Epidemiologic classification of human papillomavirus types associated with cervical cancer. N Engl J Med 2003;348:518–27.
  19. Gonzalez Joaquin V, Gutierrez Rafael A, Keszler Alicia, Del Carmen Colacino Lidia Maria V.Alonio, Teyssie Angelica R , Picconi Maria Alejandra Human Papillomavirus in oral lesions Medicina (Buenos Aires) 2007; 67: 363-368
  20. Shuichi Fujita, Masachika Senba, Atsushi Kumatori, Tomayoshi Hayashi,Tohru Ikeda, Kan Toriyama Human Papillomavirus Infection in Oral Verrucous Carcinoma: Genotyping Analysis and Inverse Correlation with p53 Expression Pathobiology. 2008;75(4):257-64