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      <PublisherName>journal-jmsr</PublisherName>
      <JournalTitle>Journal of Medical and Surgical Research</JournalTitle>
      <PISSN>I</PISSN>
      <EISSN>S</EISSN>
      <Volume-Issue>Vol. III, n 2</Volume-Issue>
      <PartNumber/>
      <IssueTopic>Multidisciplinary</IssueTopic>
      <IssueLanguage>English</IssueLanguage>
      <Season>December 2016</Season>
      <SpecialIssue>N</SpecialIssue>
      <SupplementaryIssue>N</SupplementaryIssue>
      <IssueOA>Y</IssueOA>
      <PubDate>
        <Year>-0001</Year>
        <Month>11</Month>
        <Day>30</Day>
      </PubDate>
      <ArticleType>JMSR Nephrology</ArticleType>
      <ArticleTitle>Renal Biopsy in Lupus Nephropathy: General Features and Preditors of Bad Prognosis.</ArticleTitle>
      <SubTitle/>
      <ArticleLanguage>English</ArticleLanguage>
      <ArticleOA>Y</ArticleOA>
      <FirstPage>286</FirstPage>
      <LastPage>295</LastPage>
      <AuthorList>
        <Author>
          <FirstName>Mikou</FirstName>
          <LastName>Souad</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>N</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Tarik</FirstName>
          <LastName>Sqalli</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Mohammed</FirstName>
          <LastName>Arryhani</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
        </Author>
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      <DOI/>
      <Abstract>Introduction: Lupus nephritis is one of the most serious manifestations of systemic lupus erythematosus (SLE). It__ampersandsign#39;s responsible for a high morbid-mortality in young subjects. The aim of our study is to establish lupus nephritis epidemiology in our population, histological features and predictive factors of proliferative and active injuries and predictors of bad prognosis.&#13;
&#13;
Results: Were enrolled 71 biopsies finding lupus nephritis among 700 kidney biopsies conducted in our nephrology department during the period of 6 years (10.14%).The average age of patients was 32.69 ---PlusMinusSymbol--- 11.48 years. A female predominance was observed (sex-ratio =0.2). The main indication for biopsy was the concomitant existence of proteinuria, hematuria and renal failure (48%). In univariate analysis, we retained as predictive factors of proliferative and active form: spring season flare with a maximum in June, pre-existing lupus nephritis, lymphopenia and nephrotic syndrome. Risks of progression to chronic renal failure were: female gender in 90% of cases (p</Abstract>
      <AbstractLanguage>English</AbstractLanguage>
      <Keywords>Classification, Lupus Nephritis, Renal Biopsy, Prognosis, Spring</Keywords>
      <URLs>
        <Abstract>https://www.journal-jmsr.net/ubijournal-v1copy/journals/abstract.php?article_id=4793&amp;title=Renal Biopsy in Lupus Nephropathy: General Features and Preditors of Bad Prognosis.</Abstract>
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      <References>
        <ReferencesarticleTitle>References</ReferencesarticleTitle>
        <ReferencesfirstPage>16</ReferencesfirstPage>
        <ReferenceslastPage>19</ReferenceslastPage>
        <References>Schwartz MM, Kawala KS, Corwin HL, Lewis EJ. The prognosis of segmental glomerulonephritis in systemic lupus erythematosus. Kidney Int 1987; 32:274.&#13;
	Cervera R, Khamashta MA, Font J, Sebastiani GD, Gil A, Lavilla P, et al. Morbidity and mortality in systemic lupus erythematosus during a 10-year period: a comparison of early and late manifestations in a cohort of 1000 patients. Medicine (2003); 82:299-308.&#13;
	Bastian HM, Roseman JM, McGwinJr G, Alarco´ n GS, Friedman AW, Fessler BJ, et al. Systemic lupus erythematosus in three ethnic groups. XII. Risk factors for lupus nephritis after diagnosis. Lupus in minority populations: nature vs nurture. Lupus 2002; 11(3):152-60.&#13;
	Cameron JS. Lupus nephritis. J Am Soc Nephrol 1999; 10(2):413-424.&#13;
	Molinoa C, Fabbian F, Longhini C. Clinical approach to lupus nephritis: Recent advances. European Journal of Internal Medicine 20 (2009) 447-453.&#13;
	Seligman VA, Suarez C, Lum R, Inda SE, Lin D, Li H, et al. The Fc gamma receptor IIIA-158F allele is a major risk factor for the development of lupus nephritis among Caucasians but not non Caucasians. Arthritis Rheum 2001; 44: 618-25.&#13;
	Chiche L, Jourde N, Ulmann C, Mancini J, Darque A, Bardin N and al. Seasonal variations of systemic lupus erythematosus flares in southern France European Journal of Internal Medicine 23 (2012) 250-254.&#13;
	Hasan T, Pertovaara M, Yli-Kerttula U, Luukkaala T, Korpela M. Seasonal variation of disease activity of systemic lupus erythematosus in Finland: a 1 year follow up study. Ann Rheum Dis 2004; 63:1498-500.&#13;
	Amit M, Molad Y, Kiss S, Wysenbeek AJ. Seasonal variations in manifestations and activity of systemic lupus erythematosus. Br J Rheumatol 1997; 36: 449-52.&#13;
	Haga HJ, Brun JG, Rekvig OP, Wetterberg L. Seasonal variations in activity of systemic lupus erythematosus in a subarctic region. Lupus 1999; 8: 269-73.&#13;
	Schlesinger N, Schlesinger M, Seshan SV. Seasonal variation of lupus nephritis: high prevalence of class V lupus nephritis during the winter and spring. J Rheumatol 2005; 32: 1053-7.&#13;
	Szeto CC, Mok HY, Chow KM, Lee TC, Leung JY, Li EK and al. Climatic influence on the prevalence of noncutaneous disease flare in systemic lupus erythematosus in Hong Kong. J Rheumatol 2008; 35:1031-7.&#13;
	Karras A, Martinez F. Rein et lupus : donnand;eacute;es rand;eacute;centes. Services de nand;eacute;phrologie et de transplantation rand;eacute;nale, hand;ocirc;pital Necker, 149, rue de Sand;egrave;vres, 75015 Paris, France. Revue du Rhumatisme 72 (2005) 162-167.&#13;
	Huong DL, Papo T, Beaufils H, et al. Renal involvement in systemic lupus erythematosus.A study of 180 patients from a single center. Medicine (Baltimore) 1999; 78:148.&#13;
	Cervera R, Khamashta MA, Font J, Sebastiano GD, Gil A, Lavilla P, et al. Systemic lupus erythematosus: clinical and immunologic patterns of disease expression in a cohort of 1000 patients. Medicine (Baltimore) 1993; 72:113-24.&#13;
	Martins L, Rocha G, Rodrigues A, Santos J, Vasconcelos C, Correia J, et al. Lupus nephritis a retrospective review of 78 cases from a single center. Clin Nephrol 2002; 57:114-9.&#13;
	David Cimbaluk. Pathology, classification and pathogenesis of lupus glomerulonephritis. Mini-symposium: pathology of medical renal disease, diagnostic histopathology 19:5, 2013.&#13;
	Korbet SM, Schwartz MM. The pathology, pathogenesis and clinical features of severe lupus nephritis. In: Lewis EJ, Schwartz MM, Korbet SM, Chan TM, eds. Lupus nephritis. 2ndedn. Oxford: Oxford University Press, 2011; 129e67.&#13;
	Weening JJ, Dand;#39;Agati VD, Schwartz MM, et al. The classification of glomerulonephritis in systemic lupus erythematosus revisited. J Am SocNephrol 2004; 15:241.&#13;
	A Karras. Atteinte rand;eacute;nale du lupus and;eacute;rythand;eacute;mateux dissand;eacute;minand;eacute;. Presse Med, (2012) 41 : 260-266.&#13;
	Houssiau F. A. Nand;eacute;phropathie du lupus, La Revue de mand;eacute;decine interne 28S (2007) S304-S305.&#13;
	KDIGO Clinical Practice Guideline for Glomerulonephritis Kidney International Supplements (2012) 2, V II.&#13;
	Band;eacute;ji S, Kaaroud H, Ben Moussa F, Abderrahim E, Goucha R, Ben Hamida Fand al. Nand;eacute;phropathie lupique : and;agrave; propos de 211 cas. (2005) 8-12.&#13;
	Sharon L, Kolasinski, James B, Albert DA. What do we know about lupus membranous nephropathy? An analytic review. Arthritis and Rheumatism 2002; 47:450-5.&#13;
	Martins L, Rocha G, Rodrigues A, Santos J,Vasconcelos C, Correia J, et al. Lupus nephritis a retrospective review of 78 cases from a single center. ClinNephrol 2002; 57:114-9.&#13;
	Bomback AS, Appel GB. Updates on the treatment of lupus nephritis.J Am SocNephrol 2010; 21:2028.&#13;
	Mac Gowan JR, Ellis S, Griffiths M, Isenberg DA. Retrospective analysis of outcome in a cohort of patients with lupus nephritis treated between 1977 and 1999. Rheumatology2002; 41:981-7.</References>
      </References>
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